Endocrine Abstracts

Patients with hypoparathyroidism are at risk of short-term and long-term complications and comorbidities, such as renal, cardiovascular, metabolic or cognitive manifestations. The purpose of this study was to determine the burden of illness (BOI) in patients with not adequately controlled chronic hypoparathyroidism receiving conventional therapy (oral calcium supplements and active vitamin D) in Belgium and the Netherlands. Data werecollected from a cross-sectional, 2-part onl...

Introduction: Low energy trauma fractures are prevalent in end-stage liver disease and after orthotopic liver transplantation (OLT). However, data on bone mineral density (BMD) are scarce in these patients. In this study, we evaluated the natural course of changes in BMD after successful OLT.Study design: All recipients of a successful OLT between 2000 and 2011 from the Leiden University Medical Centre, in whom BMD data were available, were included. Pat...

Introduction: Osteoporosis and fractures are common in liver disease and fracture incidence increases after orthotopic liver transplantation (OLT). The value of bone turnover markers (BMTs) in the prediction of bone loss and fracture risk pre- and post-OLT is not known.Study design: The BMTs P1NP, osteocalcin, BALP and CTX were measured initially or in Biobank stored sera at screening and at 3, 6 and 12 months post-OLT in consecutive OLT recipients betwe...

Pseudohypoparathyroidism (PHP) and related disorders lead to a wide spectrum of abnormal physical characteristics, neurocognitive and endocrine abnormalities that share a common PTH/PTHrP signaling pathway. The clinical and molecular overlap of PHP and related disorders lead to difficulties in clinical and molecular diagnosis which prompt to the possibility of incorrect management of these patients. PHP (including all subtypes), pseudoPHP, acrodysostosis and progressive osseou...